Michael Iles, owner of Salon Drosha, has been commuting through the intersection for 11 years and describes the congestion as a significant issue. "I have been doing this commute to and from work ...

Moreover, the failure of bovine milk exosomes to rescue Drosha knockout mice—genetically modified mice with a loss of microRNA maturation—indicates the need for further investigation to comprehend the ...

Figure 1 MiRNA biogenesis and function. Generally, miRNA first transcribe longer pri-miRNA, and pri-miRNA are then cleaved to pre-miRNA by Drosha and Pasha/DGCR8 in the nucleus. Subsequently, the ...

The yeast nuclear endonuclease Rnt1 has a well-characterized role in the maturation of many ncRNA precursors. However, the scope and consequence of its function in mRNA degradation pathways is much ...

MicroRNAs (miRNAs) are expressed by cells that constitute the immune system, and they function by repressing specific mRNA targets at the post-transcriptional level. The biosynthesis of miRNAs ...

Department of Pathology, School of Medicine, Yale University, New Haven, Connecticut 06520, United States ...