Ancient DNA is telling us more and more about humans and environments long past. Could it also help rescue the future?

Deputy speaker of the Assembly, Steven Aiken, has spoken out about the importance of early screening for the ‘Celtic Curse’ – ...

Olaparib plus abiraterone improved survival vs placebo in BRCA-mutated metastatic castration-resistant prostate cancer.

This is an important and solid study that examines the role of TFAM, a protein that helps maintain mtDNA, in mtDNA mutator mice. The authors have demonstrated that TFAM's counteractive role in mtDNA ...

More than a year after a massive great white shark washed ashore in southwestern ... sparked speculation. Now, DNA analysis has revealed that orcas and broadnose sevengill sharks were involved ...

1Division of Cancer Genome Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), and National Center for Tumor Diseases (NCT), Heidelberg, Germany 2German Center for Lung ...

A new study in the journal Nature throws a new theory into the fray. Analyzing a wealth of DNA collected from fossilized human bones, the researchers found that the first Indo-European speakers ...

mumc.nl Background Severe, disease-causing germline mitochondrial (mt)DNA mutations are maternally inherited or arise de novo. Strategies to prevent transmission are generally available, but depend on ...

Ancient DNA locates the geographic origin of Proto-Indo-Europeans and Proto-Anatolians and describes their early migrations out of the Caucasus Lower Volga and North Pontic regions of present-day ...

Contrasting the epigenetic clock theory is a competing grand unifying theory that argues somatic mutations in DNA are the fundamental cause of aging. This idea suggests that as cells replicate ...

We propose that an extended analysis of all coding regions of the UBA1 gene may uncover other mutations with putative functional consequences. References [1]Beck DB, et al. Somatic Mutations in UBA1 ...

Background While p53 mutations occur early ... rather than progressing through metaplasia. In vitro, p53 mutation enhanced BE progenitors’ organoid-forming efficiency, growth, DNA damage resistance ...