These PROTAC candidates possessed different linker configurations, and PROTAC 8 was able to cause BRD4 degradation in cells, with a half-maximal degradation concentration (DC50) of 80 nM. The authors ...

Here we go again. After years of speculation and eager anticipation, Rockstar Games has finally set a date on the calendar for Grand Theft Auto VI: May 26, 2026. But even with a firm release ...

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aInflammation and Immune-Mediated Diseases Laboratory of Anhui Province, The Key Laboratory of Anti-inflammatory of Immune Medicines, Ministry of Education, Anhui Institute of Innovative Drugs, School ...

Department of Hematology, Oncology and Cancer Immunology, Charité─Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, D-12203 Berlin, Germany ...

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Among these degraders, compound 14, with a relatively low molecular weight of 814.32 dalton, exhibits notable activity against EGFR Del19 and EGFR L858R , with DC50 values of 0.26 nM and 20.57 nM, ...