is an F-box protein that binds to key regulators of cell division and growth, including cyclin E, MYC, JUN and Notch. Most FBW7 substrates are proto-oncogenes that are broadly implicated in the ...

However, once the function of the cyclin is complete, the Skp Cullin F-box containing (SCF) complex or the anaphase promoting complex (APC) adds ubiquitins onto the cyclin via ubiquitinoylation ...

The well-studied NF-κB signaling system is a key mediator of the inflammatory response. Large-scale sequencing studies in ...

America’s best-selling electric pickup has been hit with a recall. Ford is recalling certain 2024 and 2025 F-150 Lightning electric pickups over a faulty suspension that could cause a loss of ...

E.l.f. Beauty recently signed a definitive agreement to acquire celebrity skincare brand Rhode, founded by Hailey Bieber, in a $1 billion megadeal. The agreement includes $800 million of ...

It's one of the stealthiest fighter jets in the world. The Lockheed Martin F-22 Raptor is the pinnacle of what air dominance can be. So ... it was canceled. In 2009, the U.S. Department of Defense ...

More than two and a half decades have passed since the U.S. brought together 19 countries to assist in building the renowned F-35 Lightning II fighter jet. The plane is an interesting piece of ...

The F.B.I. headquarters in Washington.Credit...Erin Schaff/The New York Times Supported by By Adam Goldman Reporting from Washington Before being confirmed as the director of the F.B.I., Kash ...

While the F-16’s arrival elevated Ukraine’s aerial abilities, it has not turned the tide of the war. While Ukrainian officials had hoped that a contingent of American-made F-16 Fighting Falcon ...