CTCF-binding profiles remain unchanged between urea and standard ChIP-seq If cohesin and CTCF bind directly to chromatin ... The DNA binding profiles of PRC2 core subunits, Jarid2, Suz12, and Ezh2 ...

The method can effectively separate several pairs of normal and variant Hb subunits with mass shifts of less than 1 Da and accurately identify them in intact-protein and top-down analyses. A joint ...

This important study reports single-nucleus multiomics-based profiling of transcriptome and chromatin accessibility of mouse XX and XY primordial germ cells (PGCs). The main conclusions of this study, ...

Many of the cells in our bodies are quiescent, that is, temporarily not dividing. Under certain physiological conditions such as during tissue repair and maintenance, quiescent cells receive the ...

This month's cover highlights the article Nup358 restricts ER-mitochondria connectivity by modulating mTORC2/Akt/GSK3β signalling by Joseph, Misha Kalarikkal and colleagues. The image shows a human ...

Protein-DNA interactions are responsible for a large part of the gene expression regulation. Proteins such as transcription factors as well as histones are directly related to how much and in which ...

Bioprocessing Technology Institute (BTI), Agency for Science, Technology and Research (A*STAR), 20 Biopolis Way, #06-01 Centros, Singapore 138668, Singapore ...