CDC25A, B and C expression and activity is tightly regulated by many mechanisms, including alternative exon splicing, phosphorylation–dephosphorylation cycles, interactions with partners such as ...

At the molecular level, SMYD3 inhibition led to sustained activation of CDC25A within oocytes, facilitating GVBD but impeding the MI-MII transition due to the absence of CDC25A degradation. Moreover, ...

Zika virus (ZIKV) infection is associated with severe neurological defects in fetuses and newborns, such as microcephaly. However, the underlying mechanisms remain to be elucidated. In this study, ...

Department of Chemistry, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada, Department of Biochemistry, Queen's University, Kingston, Ontario, K7L 3N6, Canada, and Department of Biochemistry ...

‡ Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Computational Drug Development Group, P.O. Box B, Frederick, Maryland 21702, United States § Frederick National ...

This study presents a useful finding for the ferroptosis-mediated tumor microenvironment (TME) in triple-negative breast cancer (TNBC) using public single-cell RNA sequencing (scRNA-seq) and bulk RNA ...

Triple-negative breast cancer (TNBC), an aggressive malignancy with limited tools to predict recurrence and drug sensitivity, exhibits ferroptotic heterogeneity across subtypes. However, the tumor ...