There is an elevated amounts of iron in persister cancer cells. In these cells, iron is taken up preferentially by CD44-mediated endocytosis, where iron binds to hyaluronic acid and this glycan ...

The cells responsible for the majority of cancer-related deaths are those capable of spreading throughout the body: ...

Preliminary results from a phase IIa trial of APG-157 in oral cavity and oropharyngeal dysplasia. This is an ASCO Meeting Abstract from the 2025 ASCO Annual Meeting I. This abstract does not include a ...

French biochemist Raphaël Rodriguez co-developed an experimental drug targeting metastasis-the spread of cancer responsible ...

AIMS This study was undertaken to confirm the distribution and expression of the molecule CD44 on human corneas under normal and pathological conditions. METHODS Fifty eight corneal buttons from adult ...

Recently, we demonstrated that CD44 promotes spontaneous distant metastasis in a CRC xenograft model. The depletion of CD44 was associated with reduction in hypoxia, EMT, as well as improved ...

Sodium hyaluronate is the ligand for CD44, a cell surface adhesion molecule which has been found on normal human corneal epithelial cells. The purpose of this study was to investigate the effect of ...

Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska ...

Biomedical Polymers Laboratory, and Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, College of Chemistry, Chemical Engineering and Materials Science, and State Key ...

The newly generated CD4 single-positive (SP) T lymphocytes are featured by enhanced IL-4 but repressed IFN-γ production. The mechanisms underlying this functional bias remain elusive. Previous studies ...