CYP3A enzymes, a major subset of the cytochrome P450 superfamily, play a central role in the metabolism of approximately half of all clinically used drugs. Interindividual variability in CYP3A ...

Researchers have discovered that plant-derived phytochemicals and their gut microbiome metabolites control the effectiveness ...

CYP3A Inhibitors: When BRUKINSA is co-administered with a strong CYP3A inhibitor, reduce BRUKINSA dose to 80 mg once daily. For coadministration with a moderate CYP3A inhibitor, reduce BRUKINSA ...

CYP3A Inhibitors: When BRUKINSA is co-administered with a strong CYP3A inhibitor, reduce BRUKINSA dose to 80 mg once daily. For coadministration with a moderate CYP3A inhibitor, reduce BRUKINSA dose ...

Vertex Pharmaceuticals Incorporated (Nasdaq: VRTX) today announced data across multiple studies demonstrating positive ...

Travere Therapeutics, Inc., today announced that the Company will present seven abstracts at the upcoming European Renal Association (ERA) Congress in Vienna, Austria, June 4-7. Presentations will ...

CYP3A activities are the sum of the activities of at least three CYP3A isoenzymes: CYP3A4, CYP3A5, and CYP3A7. [77,78] Interindividual variability due to CYP3A4 activity alone may vary by up to 50 ...