"Notably, unlike clopidogrel, which is metabolically activated via cytochrome P450 2C19 (CYP2C19), prasugrel is primarily activated through cytochrome P450 3A4 and 2B6," Kang and colleagues wrote.

Expert Rev Clin Pharmacol. 2012;5(3):319-336. Finally, a recent study suggested that although prasugrel significantly reduces thrombotic events in patients with ACS undergoing PCI because of its ...

CYP2C19*3 is mainly found in the Japanese population. There are also ethnic differences in the frequency of the poor metabolizer phenotype. About 3-5% of Caucasians and 12- 23% of most Asian ...

Hypertrophic cardiomyopathy (HCM), the most common inherited cardiovascular disease, accounts for a substantial number of cases of heart failure and sudden death.1 2 Resting or physiologically ...