Recent advances in cancer research have underscored the critical role of myeloid cells in shaping tumor microenvironments (TME), influencing tumor progression, immune evasion, and therapeutic ...

Chemokines articles from across Nature Portfolio. Atom; RSS Feed; Definition. Chemokines are a class of cytokine protein that act as signalling molecules, regulating immune and inflammatory ...

The chemokine receptor CXCR2 is expressed on various immune cells and is essential for neutrophil recruitment and angiogenesis at sites of acute and chronic inflammation caused by tissue injury or ...

Thus, CXCR2 functions of MIF clearly require the pseudo-(E)LR motif, in particular the Arg-11 residue, which parallels the structure–function requirements of other CXCR2 ligands. Fig. 5. The pseudo-(E ...

N,N‘-Diarylureas were prepared, and the structure−activity relationship relative to the CXCR2 receptor was examined. This led to the identification of a potent and highly selective CXCR2 antagonist, ...

Background: A study was undertaken to test the hypothesis that severe exacerbations of asthma are characterised by increased bronchial mucosal neutrophilia associated with upregulation of neutrophil ...

Abnormal chemokine secretion in the tumor microenvironment disrupts these gradients; for example, CCR2/CCL2 and CXCR2/CXCL1 recruit immunosuppressive cells such as myeloid-derived suppressor cells, ...

Objective Alcohol use in metabolic dysfunction-associated steatohepatitis (MASH) is associated with an increased risk of fibrosis and liver-related death. Here, we aimed to identify a mechanism ...

Objectives Single-cell and spatial transcriptomics analysis of human knee articular cartilage tissue to present a comprehensive transcriptome landscape and osteoarthritis (OA)-critical cell ...

Regnase-1 is a ribonuclease that regulates inflammation in immune cells by degrading cytokine mRNA. Regnase-1 was identified as one of the frequently mutated genes in the inflamed colorectal ...

Most of the human gastric cancer (GC) worldwide are ascribed to Helicobacter pylori infections, which have a detrimental effect on the immunotherapy’s efficacy.Comprehensively dissecting the key cell ...