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Frontiers10d
Integration of Single-cell RNA and Bulk RNA sequencing revealed malignant ductal cell heterogeneity and prognosis signatures in pancreatic cancer
Pyscenic and CellPhoneDB analysis revealed that high-expression malignant ductal cells interact with M0 macrophages through CXCL14-CXCR4 and IL1RAP-PTPRF, with SPI1 being an upstream transcription ...
Frontiers15d
Single cell dissection reveals SFRP2+ fibroblasts amplifying inflammatory responses in oral lichen planus
Compared to the healthy control group, upregulated expressions of pro-inflammatory molecules (CXCL12, CXCL14) and antigen presenting associated molecules (HLA-A, HLA-B, HLA-C and ERAP2) were displayed ...
C&EN1d
Single-Cell Analysis Reveals Cxcl14 + Fibroblast Accumulation in Regenerating Diabetic Wounds Treated by Hydrogel-Delivering Carbon Monoxide
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eLife14d
The integration mechanism of the four positional cues—anterior, posterior, dorsal, and ventral—in axolotl limb regeneration
This fundamental work by Yamamoto and colleagues advances our understanding of how positional information is coordinated between axes during limb outgrowth and patterning. They provide solid evidence ...
C&EN24d
Advances in Epigenomic Sequencing and Their Applications in Cancer Diagnostics
Department of Pathology, Yale School of Medicine, New Haven, Connecticut 06510, United States Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut 06510, United States Department of ...
PNAS10d
Epigenetic switch reshapes epithelial progenitor cell signatures and drives inflammatory pathogenesis in hidradenitis suppurativa
Hidradenitis suppurativa (HS) is a complex inflammatory skin disease with undefined mechanistic underpinnings. Here, we investigated HS epithelial cells and demonstrated that HS basal progenitors ...