Frabin is an actin filament-binding protein which shows GDP/GTP exchange activity specific for Cdc42 small G protein and induces filopodium-like microspike formation and c-Jun N-terminal kinase ...

Three recent papers have reported the surprising finding that Cdc42 and Rac1, both of which are known to be involved in maintaining apico-basolateral polarity of epithelial cells, can each bind to ...

Nervous necrosis virus typically enters host cells via endocytosis, but it can also enter via a process called macropinocytosis.

In this manuscript, the authors discovered MYL3 of marine medaka (Oryzias melastigma) as a novel NNV entry receptor, elucidating its facilitation of RGNNV entry into host cells through ...

Aims To characterise the nature of neonatal cytopenia in an infant presenting with a CDC42 mutation and NOCARH – neonatal-onset cytopenia with dyshaematopoiesis, autoinflammation, rash, and ...

This function of Ste20 in the HOG pathway requires binding of the small GTPase Cdc42. Overexpression of Cdc42 partially complements the osmosensitivity of ste20Δ mutants, perhaps by activating another ...

During the growth processes, we identified and experimentally demonstrated that both Rho GTPase Cdc42 signaling-mediated cell cortex distribution and the stability of tight junctions (TJs) were ...

Biophysical forces generated by normal respiration maintain AT1 cell identity and limit its differentiation into AT2 cells through the Cdc42 and Ptk 2 pathways. Epithelial injury signaling in the ...

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