Immunostaining (APAAP method) was performed on frozen cryostat sections with a panel of monoclonal antibodies to total leucocytes (CD45), T lymphocyte phenotypic markers (CD3, CD4, CD8), macrophages ...

Perivascular hypercellular areas stained uniformly with CD31 and less so with VEGFr2. Additionally, focal areas of Ki67+ and CD68+ cells were found in these regions. Expanded stroma contained CD31+ ...

Inflammatory cell markers CD66b and CD68 also exhibited significant cohort differences (p<0.05). Exploratory analyses revealed a significant relationship between tumour immunity factors, geographic ...

and CD68+ (p<0.001) cell infiltration, blood vessel formation (p = 0.01), vascular endothelial growth factor (p = 0.001), and intercellular adhesion molecule-1 expression (p<0.001). Numbers of cells ...

MRI analysis revealed higher ADC entropy in patients with partial response. Exploratory analysis showed increased PD-L1 + CD68+ macrophages and PD-1 + CD8+ T cells in the tumor stroma of partial and ...

Mantle Cell Lymphoma: Optimal Treatment With Bruton Tyrosine Kinase–Targeted Approaches PD-1 immune checkpoint blockade administered subsequent to rather than concurrent with chemoradiotherapy for ...

Aortic dissection (AD) is the separation of medial layers of the aorta and is a major cause of death in patients with connective tissue disorders such as Marfan syndrome. However, molecular triggers ...

Correspondence to Professor Shiquan Sun, Xi'an Jiaotong University, Xi'an, Shaanxi, China; sqsunsph{at}xjtu.edu.cn; Professor Guangdun Peng, Chinese Academy of Sciences, Guangzhou, Guangdong, China; ...

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