Rapt Therapeutics has conducted its second round of layoffs in just under a year, continuing a period of upheaval following ...

There is no curative treatment at the moment, although various drugs, including chemotherapy, retinoids, interferons, HDAC inhibitors, and Kyowa Kirin’s anti-CCR4 antibody Poteligeo ...

The company’s lead inflammation drug candidate is zelnecirnon (RPT193), a C-C motif chemokine receptor 4 (CCR4) antagonist that selectively inhibit the migration of type 2 T helper cells into inflamed ...

1:100), CD194(CCR4)-PE/Dazzle 594 (Biolegend, USA, 1:200), CD161-BV650 (BD Biosciences, USA, 1:100), CD45RO-BUV395 (BD Biosciences, USA, 1:120) and CD45RA-BV605 (BD Biosciences, USA, 1:150). T cells ...

The yeast nuclear endonuclease Rnt1 has a well-characterized role in the maturation of many ncRNA precursors. However, the scope and consequence of its function in mRNA degradation pathways is much ...

Of the 117 patients enrolled, 116 completed chemotherapy, with the median age of 32 years: 50% men, 98% stage II, 86% Memorial Sloan Kettering–defined disease bulk, 27% traditional bulk (> 10 cm), 52% ...

1 Jiangxi Provincial Key Laboratory of Environmental Pollution Prevention and Control in Mining and Metallurgy, Jiangxi University of Science and Technology, Ganzhou, China 2 Institute of ...

1Department of Biological Sciences and CERMO-FC Research Centre, Université du Québec à Montréal (UQAM), Montreal, QC, Canada 2Research Institute of McGill University Health Centre, Montreal, QC, ...