In addition to rod photoreceptor loss, many mutations in rod photoreceptor-specific genes cause degeneration of other neuronal types. Identifying mechanisms of cell–cell interactions initiated ...

Atsena Therapeutics, a clinical-stage gene therapy company focused on bringing the life-changing power of genetic medicine to reverse or prevent blindness, today announced that safety and efficacy ...

RS1 is localized to the extracellular surface of rods, cones, and bipolar cells. XLRS is characterized by schisis, or abnormal splitting of retinal layers, which causes impaired visual acuity that is ...

These include retinal pigment epithelial cells (RPE), rod and cone photoreceptor cells, horizontal cells, rod and cone bipolar cells, Müller cells, amacrine cells, retinal ganglion cells, microglia, ...

notably impacting rod photoreceptors and specific inflammatory cell subsets. Differential gene expression analysis of rods, cones, and bipolar cells (BCs) identified a common upregulation of pathways ...

This study demonstrates the critical role of Afadin on the generation and maintenance of complex cellular layers in the mouse retina. The data are solid, which provides important insights into how ...

A critical component of the hydrogen fuel cell is the bipolar plate, which facilitates the electrochemical processes that produce electricity. Bipolar plates distribute reactant gases — hydrogen at ...

However, the study provides limited new insights into the relationship between retinal lamination defects and overall retinal function. Neural lamination is a common feature of the central nervous ...

When light enters the eye, it activates the retina’s photoreceptor cells — cones and rods — that enable vision. Behind the retina lies the choroid, a dense network of blood vessels key for delivering ...

Inside the retina, there are millions of special sense receptors called rods and cones. The rods see the shapes of things, picking out black, white and shades of grey, and the cones see the ...