Researchers have found inactivating mutations in the ARID2 gene in 18.2% of patients with HCV-associated hepatocellular carcinoma (HCV-associated HCC). The international team, led by Michael S ...

Mutation of a gene called ARID2 plays a role in increasing the chance that melanoma, a deadly skin cancer, will turn dangerously metastatic, Mount Sinai researchers report.

ARID2 is part of a chromatin remodeling complex and frequently mutated in melanoma. In this study, scientists used melanoma tumor models to measure the role of the ARID2 gene in cancer progression.

The scientists also showed that ARID2 expression is associated with a poor prognosis and is higher in patients with relapsed or refractory multiple myeloma, most of whom acquire resistance to ...

Dr Simon Vincent, Breast Cancer Now’s director of research, support and influencing said: “ Each year around 8,000 UK women are diagnosed with triple negative breast cancer, which is usually a more ...