This protein, called AP2A1, could be the key to future treatments that will turn back the body's biological clock and undo the damage caused by old age. As our bodies get older, we build up a ...

Other inhibited regulators include PTH (parathyroid hormone), NFATC2 (nuclear factor of activated T-cells, cytoplasmic 2), and several adaptor proteins such as AP2A1, AP2A2, AP2B1, AP2M1, AP2S1, and ...

Contributed by J. Wade Harper; received September 23, 2024; accepted October 30, 2024; reviewed by Pietro V. De Camilli and Michael Lazarou This contribution is part of the special series of Inaugural ...

The molecular complexity of mammalian proteomes demands new methods for mapping the organization of multiprotein complexes. Here, we combine mouse genetics and proteomics to characterize synapse ...

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