High-throughput compound screening indicated that ox-LDL-induced CD147 upregulation in macrophages was achieved through PI3K/Akt/mTOR signaling ... in the absence or presence of the LXR agonist GW3965 ...

The facade of the 118-room Sax Paris, LXR Hotels & Resorts. Photo Credit: Hilton Hilton has opened its first luxury property in Paris' city center with the debut of the Sax Paris, LXR Hotels ...

LXR Hotels & Resorts, Hilton's collection of independent luxury properties, has announced the launch of the "Pursuit of Adventure" program, a brand-wide initiative celebrating the timeless pursuit of ...

In amongst a clutch of discontinued phase 3 programmes in Roche's fourth-quarter results update was the news that it has stopped a study of AKT inhibitor ipatasertib as a treatment for first-line ...

Get Instant Summarized Text (Gist) In adults with diabetes and obesity, use of GLP-1 receptor agonists is associated with a modestly lower risk of obesity-related cancers and all-cause mortality ...

Hepatocarcinoma is the most commonly diagnosed form of liver cancer. It is an aggressive, fast growing cancer with a 5-year survival rate of only 15%. Thomas Jefferson University researcher Gyorgy ...

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Characterisation of AKT regulation in this setting will provide new strategies to combat liver cancer. Conclusions Our results highlight a fine-tuned regulation of AKT by S6K1-mediated phosphorylation ...