Concurrently, the company's isoform-selective AMPK activator, BLX-0871, showed dual benefits in preclinical studies: effective weight reduction and significant preservation of lean muscle mass ...

If you're not looking to go all out with your desktop PC, playing graphically intense games, or doing heavy photo and video editing, the chances are pretty high that you're going to be happy with ...

The AMP-activated protein kinase (AMPK) system acts as a sensor of cellular energy status that is conserved in all eukaryotic cells. It is activated by increases in the cellular AMP:ATP ratio caused ...

Primary myoblasts were inoculated in 96-well plates, transfected with siRNA or pcDNA3.1 vectors and cultured for 24 h. CCK-8 solution (10 μL, Beyotime, Jiangsu, China) was added to each well and ...

Abstract: Adenylate Kinase-2 (AK2) activity increases in cancer cells which results in high demand of energy supply through anaerobic metabolism. Bis(adenosine)-5’- pentaphosphate (Ap5a) is a ...

Furthermore, it was observed that phosphorylation levels of AMPK (Thr-172) decreased in LPS-stimulated BV2 microglia. Vinpocetine treatment increased AMPK phosphorylation in LPS-stimulated BV2 ...

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elegans AMPK activates the DAF-16/FOXO transcription factor, which up-regulates various antioxidant genes, including superoxide dismutases and catalases (37, 57). Mammalian AMPK also increases the ...