It achieves this by dysregulating crucial signaling pathways, including TGF-β, PI3K/AKT/mTOR, Wnt/β-catenin, Hippo/YAP, ...

HOXB13, a B-class homeobox transcription factor, sits at the hub of developmental gene networks yet has emerged as a double-edged sword in human cancer. While indispensable for embryonic patterning ...

Monther Abu-Remaileh, Gregory A. Wyant, Choah Kim, Nouf N. Laqtom, Maria Abbasi, Sze Ham Chan, Elizaveta Freinkman, David M. Sabatini, Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent ...

Tongguang Wang, Marie Medynets, Kory R. Johnson, Tara T. Doucet-O’Hare, Brianna DiSanza, Wenxue Li, Yadi Xu, Anna Bagnell, Richa Tyagi, Kevon Sampson, Nasir Malik, Joseph Steiner, Alina Hadegan, ...

The reciprocal regulation of the PLK1-mTOR axis is crucial in sepsis-induced intestinal barrier dysfunction. These findings indicate that the PLK1-mTOR axis may be a promising therapeutic target ...

When animals with this protein, which tricks mTOR, reach maturity, the functioning of the cells begins to fail and characteristic symptoms of aging are detected: the skin becomes thinner, and ...

The mammalian target of rapamycin (mTOR) protein, a member of the phosphoinositide 3-kinase (PI3K)-related protein kinase (PIKK) family, has a central role in two growth-regulatory pathways that have ...