Cre-loxP organisms are generally produced by separately creating Cre-lineage and loxP-lineage individuals that contain the ...

The offspring are heterozygous for the floxed target gene (C) and breed with the homozygous floxed mouse (B). The resulting experimental mouse is hemizygous for Cre and homozygous for loxP (D). This ...

Researchers at the University of Tsukuba have developed a vector that integrates the Cre enzyme gene with the specific DNA sequence loxP, which is its target. This vector allows the creation of ...

In this study, the researchers succeeded in synthesizing a Cre-loxP integrated vector by placing a short DNA sequence called TAx9 before the promoter region of the Cre gene, thereby preventing its ...