Methods: In a phase II, open-label, multicenter study, 65 adult patients with Ph- ALL in second relapse or who progressed after two prior lines of treatment received VSLI 2.25 mg/m 2 with no dose cap ...

The outcome of chemotherapy for Ph chromosome (Ph)-negative ALL in adult patients is inferior to that in children. Although about 90% of patients achieve CR, most of them eventually relapse, and ...