Progressive kidney failure is a genetically and clinically heterogeneous group of disorders. Podocyte foot processes and the interposed glomerular slit diaphragm are essential components of the ...

Increased TRPC6 activity from enhanced gene expression or gain-of-function mutations contribute to cardiac and/or renal disease. Despite evidence supporting a pathophysiological role, no orally ...

Blocking a certain type of ion channel has been shown to prolong survival in mouse models of severe Duchenne muscular dystrophy (DMD), which could lead to the development of novel treatments in humans ...

Journal reference: Lin, B.L., et al. (2022) Pharmacological TRPC6 inhibition improves survival and muscle function in mice with duchenne muscular dystrophy.

Modeling non-syndromic autism and the impact of TRPC6 disruption in human neurons. Molecular Psychiatry, 2014; DOI: 10.1038/mp.2014.141 ...

INGELHEIM, Germany-- (BUSINESS WIRE)--Boehringer Ingelheim today announced the initiation of a Phase 2 clinical trial of BI 764198, an inhibitor of TRPC6, a receptor-operated cation channel.

We found that blocking TRPC6 prevented this excess calcium from entering the heart and reduced arrhythmia," Kass says. "We thought maybe a long-term TRPC6 blocker would help with this syndrome.