Based on the findings from the EURO-SKI trial along with supporting evidence from DESTINY and other studies, Mahon feels confident that TKI cessation will soon be incorporated into various treatment ...

"Hopefully, data from EURO-SKI and other TKI-cessation trials made available now can form the basis for guidelines when moving the stop-TKI concept in CML to the clinic," he told .

Dr. Mauro: The main risks are straightforward: Treatment cessation under the correct circumstances (proper patient profile and correct monitoring and approach to retreatment) means that this is a ...

François-Xavier Mahon, MD, PhD, of Bordeaux Segalen University, Bordeaux, France; reviewed and summarized some of the recent studies related to TKI cessation in patients with deep molecular ...

Studies examine TKI cessation and dose reductionSekeres said he was somewhat reassured by the findings from Copland's group that only 12 of the 174 patients relapsed. But to some extent, "they ...

The yield of detection was significantly higher after TKI cessation for the baseline mutation (mean semi-quantitative index 5.2±6.2 on d0 and 6.1±6.4 on d6/7; p = .043) but not for T790M (p = .46).

The ongoing global, single arm, open label Phase 2 portion is designed with registrational intent for TKI-naïve and TKI pre-treated patients with ROS1-positive NSCLC. Story Continues and ...

The EURO-SKI study is a global trial, that is designed to assess the duration of MMR after halting TKI treatment. Of the 755 participants on this trial, Mahon said that the probability of being ...