Paired BCR and TCR data were available for 542 individuals ... clustering of complementarity-determining region 3 (CDR3) sequences to identify disease-associated patterns, and 3) embeddings ...

The TCR repertoire encapsulates the diversity of ... Three key complementarity-determining regions (CDRs) drive antigen recognition, with CDR3 exhibiting the highest variability.

The specificity of T cell recognition is determined by the variable (V) domain of the T cell receptor (TCR) α and β chains 1. TCR-peptide–MHC (pMHC) class I complexes for which crystal ...