SIRT6 regulates fat metabolism by activating another protein called peroxisome proliferator-activated receptor alpha (PPAR-alpha). 'SIRT6 is like a juggler that coordinates between metabolic ...

Surprisingly, however, the Tg.SIRT6 mice fed a HF-HS diet did not develop obesity. This unexpected finding demonstrated that over-expression of SIRT6 can prevent the development of obesity under ...

However, after being genetically modified to boost SIRT6, the mice could generate energy from those sources. They also were less susceptible to cancer, had lower cholesterol, and could run faster.

LONDON, UK/ ACCESS Newswire/ February 20, 2025/ Genflow Biosciences Plc an emerging leader in the field of longevity research, focused on developing therapeutic solutions for the prevention of age ...

To find out, Cheng and colleagues measured SIRT6 and APP protein levels in brain extracts of 3- and 24-month-old wild-type mice. The old mice had less SIRT6 and more APP in the cortex and hippocampus ...

SIRT6 belongs to the sirtuin family of protein lysine deacetylases, which regulate aging and genome stability. We found that human SIRT6 has a role in promoting DNA end resection, a crucial step in ...

"SIRT6 over-expression may prevent progression of diabetes, study finds." ScienceDaily. ScienceDaily, 19 July 2019. <www.sciencedaily.com / releases / 2019 / 07 / 190718140443.htm>.