Original Article Open access Published: 21 July 2015 Evidence that the rab5 effector APPL1 mediates APP-βCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer’s disease S Kim, Y ...

Might endosomal malfunctions drive neurodegeneration, even when Aβ is not accumulating? To address this question, first author Anna Pensalfini and colleagues generated a mouse that overexpresses a Myc ...

Damaged mitochondria pose a lethal threat to cells that necessitates their prompt removal. The currently recognized mechanism for disposal of mitochondria is autophagy, where damaged organelles ...

Here, we discovered that Rab5 also interacts directly with PI 5- and PI 4-phosphatases and stimulates their activity. Rab5 regulates the production of phosphatidylinositol 3-phosphate (PtdIns [3]P) ...