Olanzapine has previously been shown to have predominant metabolism by cytochrome (CYP) P450 1A2. Caffeine has been shown to provide an accurate phenotypic probe for measuring CYP1A2 activity. The ...

Functional Interactions between Cytochromes P450 1A2 and 2B4 Require Both Enzymes to Reside in the Same Phospholipid Vesicle: Evidence for Physical Complex Formation.

To clarify partly inconsistent results in gene expression of cytochromes P450 (CYP) in the circulation, we undertook a systematic study over a long time period in 19 healthy men and women. CYP ...

Newsletter Interesting paper out in JAMA, Coffee, CYP1A2 genotype, and risk of myocardial infarction: The association between coffee intake and risk of myocardial infarction (MI) remains controversial ...

In vivo, 85% of the clopidogrel dose is inactivated by plasma esterases. The remaining 15% is bioactivated in a 2-step pathway that depends on the cytochrome P450 isoenzyme system. The specific ...

Cytochrome P450 (CYP450), is a family of hemoglobin-coupled monooxygenases. In mammals, CYP450 oxidizes steroids, fatty acids, and xenobiotics, playing an important role in the metabolism of various ...

Rant over.) The CYP enzyme that metabolizes caffeine is called CYP1A2 (an abbreviation for Cytochrome P450 1A2). Here's the metabolic pathway. Caffeine undergoes oxidative demethylation at 3 sites.

So back to my genes. We metabolize caffeine thanks to a liver enzyme called cytochrome P450 1A2. The enzyme is produced by a gene dubbed CYP1A2.

Protective effect of tea polyphenols against paracetamol-induced hepatotoxicity in mice is significanly correlated with cytochrome P450 suppression. World J Gastroenterol 2009; 15 (15): 1829-1835 ...

This is because birth control inhibits cytochrome P450 1A2, the enzyme which breaks down caffeine in the body.