Figure 6: Myc inhibition triggers micro- and multinucleation and mitotic abnormalities in U87MG cells. Figure 7: Omomyc causes alterations in proteins linked to mitotic cell death. These results ...

Westbrook, M.D., and colleagues claim. “Loss of SUMOylation leads to substantial mitotic catastrophe and cell death by switching a subprogram of Myc transcriptional targets that support mitotic ...

Myc inhibition leads to "defects" in tumor cells and often results in their death by inducing mitotic aberrations, thus halting normal cell division. "Our results undoubtedly show that Myc ...

However, in surprising contrast, c-Myc-overexpressing cells showed a significant number of mitotic cells after γ-irradiation. The effects were even clearer in the presence of nocodazole (Figure ...

MYC is dysregulated in nearly 70% of human cancers, where it influences a vast network of biological processes including cell cycle control, metabolism, apoptosis, angiogenesis, and immune evasion.

Study: MYC-Targeting Inhibitors Generated from a Stereodiversified Bicyclic Peptide Library. Image Credit: Christoph Burgstedt / Shutterstock.com MYC, a transcription factor involved in most human ...

Inhibiting RMB42 disrupted production of Myc proteins in pancreatic cancer cells. This approach could curtail the growth of several cancer types. A review paper published last year in European ...

Cancer biologist Linda Penn of the Ontario Cancer Institute and the University of Toronto in Canada, who was not involved in the study, noted that Myc’s apparent broad role in aging comes as a ...

Myc inhibition leads to "defects" in tumor cells and often results in their death by inducing mitotic aberrations, thus halting normal cell division. "Our results undoubtedly show that Myc ...

Myc inhibition leads to "defects" in tumor cells and often results in their death by inducing mitotic aberrations, thus halting normal cell division. "Our results undoubtedly show that Myc inhibition ...

Myc inhibition leads to "defects" in tumor cells and often results in their death by inducing mitotic aberrations, thus halting normal cell division. "Our results undoubtedly show that Myc inhibition ...