Mitogen-activated protein kinase (MAPK) is an integral component of cellular signaling during mitogenesis and differentiation of mitotic cells. Recently MAPK activation in post-mitotic cells has ...

Novel PROTAC enhances its intracellular accumulation and protein knockdown Date: August 26, 2020 Source: Baylor College of Medicine Summary: Researchers have developed an improved type of PROTAC ...

A first-in-human trial of Arvinas’ investigational Parkinson’s’ disease therapy, ARV-102, has been able to demonstrate a drop in the multifunctional protein that has been associated with the ...

The PROTAC market is anticipated to expand considerably in the near future, driven by the rising number of PROTAC-based drugs undergoing clinical trials from multiple companies. At present, no ...

The PROTAC candidates “… demonstrate potent antiretroviral activity in HIV-infected primary cells, supporting further development for testing in the context of HIV-1 reservoir reduction in ...

This PROTAC vaccine technology could also be useful for generating live-attenuated vaccines against other types of pathogens." Prof. Si Longlong from the Shenzhen Institute of Advanced Technology ...

Article reference: Ying Wu, Congying Pu, Yixian Fu, Guoqiang Dong, Min Huang, Chunquan Sheng, NAMPT-targeting PROTAC promotes antitumor immunity via suppressing myeloi d-derived suppressor cell ...

The oral PROTAC in the deal, JMKX002992, targets the androgen receptor. Jemincare says the drug could treat those with prostate cancer that is resistant to other therapies.

Once PROTAC binds to its target protein and the ubiquitin ligase, the ligase will attach ubiquitin groups to the surface of the target protein, which tags it for degradation by the proteasome inside ...