Treatment with the MAPK inhibitor selumetinib results in tumors consisting of NOTCH-active cells only (center), but after treatment is stopped, the NOTCH-active cells give rise to new MAPK-active ...

Although Notch activation alone in tumor cells was not sufficient to induce angiogenesis, elevated levels of Jagged initiated crosstalk between tumor cells and blood vessel cells and stimulated ...

Subtype D displayed "bypass" activation of oncogenic pathways like WNT, MAPK, NOTCH, and ERBB signaling pathways. This study disclosed the clinical-relevant intertumoral heterogeneity of NSCLCs ...

Conclusions: Our results demonstrate that CCL25 activates Stat3 and MAPK pathways to contribute to pancreatic cancer proliferation. We also show potential cross-talk between Stat3 and MAPK pathways, ...

This elaborate transformation is orchestrated through the interplay of key signalling cascades, including the EGF-Ras-MAPK, Notch and Wnt pathways.