Inflammatory molecule LTB4 promotes insulin resistance in obese mice and blocking the LTB4 receptor prevents and reverses type 2 diabetes in this model Obesity causes inflammation, which can in ...

Like macrophages, nearby liver, fat and muscle cells also have LTB4 receptors on their cell surfaces and are activated when LTB4 binds them. Now, in obesity, those cells become inflamed as well ...

Intravitreal LTB4 and C5a was elevated in response to EAU and the level rose from initiation until the disease peaked at Day 21. Few LTB4 or C5a receptors were detected in healthy human donor eyes ...

The investigators were further able to show that LTB4 up-regulated several molecules involved in cell cycling and growth, such as cyclins and epidermal growth factor receptor, and decreased those ...