Once a histidine kinase senses an incident signal, it conveys this information to the cells by phosphorylating a response regulator protein.

Larkspur Biosciences, a company pioneering a new wave in cancer therapy that destroys tumors by targeting cancer cell fitness, today announced the discovery of LRK-4189, a first-in-class degrader of ...

For example, abnormal kinase activity is a hallmark of a number of cancers, with mutations in kinases like EGFR and BRAF driving uncontrolled cell proliferation and survival (Figure 1). 3,6,7 ...

To study ERK dynamics, many researchers use an ERK activity kinase translocation reporter (KTR). Our study reveals that this ERK KTR also partially senses cyclin-dependent kinase 2 (CDK2) activity, ...

Exelixis (EXEL) is developing zanzalintinib — a next-generation oral investigational tyrosine kinase inhibitor (TKI) — which ...

Use of liquid biomarker thymidine kinase activity (TKa) to predict outcome and progression in patients with metastatic breast cancer (MBC) in the GEICAM/2014-12 FLIPPER trial. Authors: Joan Albanell, ...

Increased activity of GSK-3β is directly associated with tau hyperphosphorylation and enhanced production, which leads to molecular dysfunctions, neuronal damage, and cognitive decline in AD. 1-2 ...

The first-ever image of PINK1 proteins represents a groundbreaking moment in Parkinson’s disease research. This pivotal achievement promises to enhance our understanding of the disease’s mechanisms, ...