News & Views Published: April 2005 Measuring kinase activity: finding needles in a haystack Benjamin E Turk Nature Methods 2, 251–252 (2005) Cite this article ...

When Vichem screens for clinically relevant kinase inhibitors, it uses a knowledge-base approach, consulting its Nested Chemical Library, a collection of kinase inhibitory compounds of about 110 ...

Kinase activity is frequently altered in renal cell carcinoma (RCC), and tyrosine kinase inhibitors (TKIs) are part of the standard treatment strategy in patients with metastatic disease.

Once a histidine kinase senses an incident signal, it conveys this information to the cells by phosphorylating a response regulator protein.

A protein with a unique phosphatidylinositol kinase activity was found to copurify with v-Src and Ros1, 5,7 and this same phosphatidylinositol kinase activity was later shown to be critical for ...

Masumi Eto discusses his up coming BioTechniques article on kinase activity tagged (KAT) Western blotting. Masumi Eto in his lab in Okayama Can you please introduce yourself and tell us about your ...

Larkspur Biosciences, a company pioneering a new wave in cancer therapy that destroys tumors by targeting cancer cell fitness, today announced the discovery of LRK-4189, a first-in-class degrader of ...

Kinases and kinase assays are all about domino effects. To tip the first domino in a drug development effort, try tracking kinase activity biochemically—or through signaling cascades in vivo.

To study ERK dynamics, many researchers use an ERK activity kinase translocation reporter (KTR). Our study reveals that this ERK KTR also partially senses cyclin-dependent kinase 2 (CDK2) activity, ...

The first-ever image of PINK1 proteins represents a groundbreaking moment in Parkinson’s disease research. This pivotal achievement promises to enhance our understanding of the disease’s mechanisms, ...