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KCNT1-related frontal lobe epilepsy. Seizures for these children typically start later than for those with the epileptic encephalopathy variant, but usually by adolescence.
Treatment of KCNT1-related epilepsy is aimed at controlling the seizures using anti-seizure medications, often including a "rescue" anti-seizure medication if needed.
A Clovis family is hosting a fundraiser to raise awareness and funds for research into the rare genetic mutation KCNT1, which has caused their two-month-old son Bodie to have multiple seizures a day.
The KCNT1 gene, for example, codes for a protein that maintains normal electrical activity in the brain and helps neurons communicate. But genes don't always function perfectly.
ATL-201 is Atalanta’s investigational therapy for KCNT1-related epilepsy, an early-onset seizure disorder and encephalopathy driven by gain-of-function variants in the KCNT1 gene.