Harmine is one of the few compounds that can replenish human beta cells. This plant-based ingredient is commonly used in ayahuasca, a spiritual drink long used by Indigenous groups in South America.

Harmine will block an enzyme in the pancreas (DYRK1A). The second drug is known as a GLP1 receptor agonist or a class of drugs best known for the Ozempic medicine widely used in recent years for ...

By inhibiting DYRK1A, harmine removes these brakes, allowing beta cells to proliferate. GLP1 receptor agonists work in conjunction with harmine to further stimulate beta cell proliferation.

Researchers assessed whether combining psychedelics, namely DMT and harmine as two active ingredients in ayahuasca, with meditation increases mindfulness, compassion, insight, and mystical-type ...

For the study, the natural product harmine, which is found in some plants, was combined with a widely used class of type 2 diabetes therapy called GLP1 receptor agonists.