Several groups have previously employed cryoelectron tomography and cryoelectron microscopy (cryo-EM) to study the structure of HIV-1 and SIV Env. These studies provided insight into the native ...

Therefore, Berndsen and colleagues applied their method to map the glycans on a modified HIV Env protein, BG505 SOSIP.664, which is used in an HIV vaccine currently being evaluated in clinical trials.

Current antiretroviral therapy can keep HIV in check and prevent AIDS in the vast majority of treated patients. However, as it is unable to eliminate viral reservoirs and cure the infection ...

Most current approaches rely on soluble protein-based HIV-1 envelope glycoprotein (Env) trimers, structures found on the viral surface that are essential for attaching to and entering host cells.

Image provided by the authors. The antibody, QA013.2, binds to a previously identified site on the HIV envelope (Env) protein, named V3. The V3 region of the SI virus contains a glycan modification ...

LA JOLLA, CA - March 3, 2016 - A new study from scientists at The Scripps Research Institute (TSRI) describes the high-resolution structure of the HIV protein responsible for recognition and ...

Accurate predictions of population-level changes in sequence and structural properties of HIV-1 Env using a volatility-controlled diffusion model. PLOS Biology, 2017; 15 (4): e2001549 DOI: 10.1371 ...

The envelope protein of HIV-1, or Env, is a transmembrane protein delivered to the plasma membrane by the cell’s secretory pathway. The bulk of the Env protein extends beyond the membrane, but a tail ...

The rapid mutation of Env is the main stumbling block for attempts to develop an HIV vaccine. To make progress, vaccine developers need to find a way to anticipate and match the virus over time.

In a novel study, Haynes and colleagues tested both approaches. Previously, a patient living with HIV CH505 was found to develop two bnAb lineages over a six-year infection period. Vaccines based on ...