Several groups have previously employed cryoelectron tomography and cryoelectron microscopy (cryo-EM) to study the structure of HIV-1 and SIV Env. These studies provided insight into the native ...

Therefore, Berndsen and colleagues applied their method to map the glycans on a modified HIV Env protein, BG505 SOSIP.664, which is used in an HIV vaccine currently being evaluated in clinical trials.

Therefore, Berndsen and colleagues applied their method to map the glycans on a modified HIV Env protein, BG505 SOSIP.664, which is used in an HIV vaccine currently being evaluated in clinical trials.

LA JOLLA, CA - March 3, 2016 - A new study from scientists at The Scripps Research Institute (TSRI) describes the high-resolution structure of the HIV protein responsible for recognition and ...

Most current approaches rely on soluble protein-based HIV-1 envelope glycoprotein (Env) trimers, structures found on the viral surface that are essential for attaching to and entering host cells.

The envelope protein of HIV-1, or Env, is a transmembrane protein delivered to the plasma membrane by the cell’s secretory pathway. The bulk of the Env protein extends beyond the membrane, but a tail ...

Current antiretroviral therapy can keep HIV in check and prevent AIDS in the vast majority of treated patients. However, as it is unable to eliminate viral reservoirs and cure the infection ...

Targeting HIV Reservoir in Infected CD4 T Cells by Dual-Affinity Re-targeting Molecules (DARTs) that Bind HIV Envelope and Recruit Cytotoxic T Cells. PLOS Pathogens, 2015; 11 (11): e1005233 DOI ...

In a novel study, Haynes and colleagues tested both approaches. Previously, a patient living with HIV CH505 was found to develop two bnAb lineages over a six-year infection period. Vaccines based on ...