However, in addition to HDACs, the human body has nearly 300 enzymes that also depend on zinc and therefore are potentially also inhibited by HDAC inhibitors, notes leading author Zheng Sun, Ph.D ...

Consistent with the selectivity observed in the recombinant enzyme and whole-cell assays, it was clear that the potent class IIa HDAC inhibitors TMP269 and TMP195 (2) did not affect this readout ...

To test whether increased activities of HDAC and CTSL provide a selective environment for targeted cancer therapy, we screened cancer cells for elevated levels of enzymes by measuring respective ...

HDAC enzymes play a role in the development of many diseases, including numerous cancers. Five compounds targeting HDAC enzymes are already approved as drugs.

They were then able to work out the specific features of inositol phosphates and how they bind to activate the HDAC enzyme. They then solved the crystal structure of a novel peptide inhibitor ...

One HDAC enzyme, HDAC3, seems to be necessary for the function of the other HDACs linked to the LKB1 gene, the researchers explained in the paper.

Histone deacetylase (HDAC) enzymes play a critical role in normal gene-regulation events and the maintenance of homeostasis. However, their dysregulation has been implicated in a variety of ...

The next step was to inhibit HDAC1 and 7 and assess the impact on CSCs. While there are inhibitors on the market, they target all HDAC enzymes, which can generate side effects.

Blocking enzyme linked to Alzheimer's may reverse memory loss Study suggests a new approach to developing treatments for Alzheimer's disease Date: August 8, 2017 Source: Massachusetts Institute of ...

Courtesy of David S. GoodsellHistone deacetylases (HDACs), closely associated with gene silencing, may have a broader role in the cell than previously thought. Research suggests that HDACs have been ...

Acetylon Pharmaceuticals raised $27 million in a Series B round of private equity financing to progress its lead Class II-selective HDAC inhibitor drug candidate ACY-1215 into Phase I/II clinical ...

LONDON--(BUSINESS WIRE)--The report, HDAC (histone deacetylase) inhibitors market 2019-2023, has been added to Technavio's catalog. It provides a comprehensive analysis of the market, including ...