SAN FRANCISCO, May 22, 2025--Rubedo Life Sciences, Inc. (Rubedo), an AI-driven, clinical-stage biotech focused on discovering and rapidly developing selective cellular rejuvenation medicines ...

Our lead drug candidate – RLS-1496, a potential first-in-class disease-altering GPX4 modulator – enters Phase I clinical trials in Spring 2025.

Glutathione peroxidase 4 (GPX4) is a key factor in ferroptosis, which is involved in ischemia-reperfusion injury. However, little is known about its role in hepatic ischemia-reperfusion injury (HIRI).

Keywords: Ferroptosis, GPX4, Alternative isoform, Fatty liver, Oligomerization, Methionine/choline-deficient diet, High fat-fructose/sucrose diet, Protein interaction ...

Neutrophils, vital for pathogen defense, are sensitive to ferroptosis. In stroke and systemic lupus erythematosus (SLE), ferroptosis in neutrophils results from reduced PPAR-γ and GPX4 expression ...