Multiple observations indicate the link between prostate carcinogenesis, stress of endoplasmic reticulum (ER stress), and impairment of Golgi morphology. We reported that PCa cells employ a ...

Within hours of turning on α-synuclein, the cells began to lose viability. ER stress, in response to the accumulation of misfolded proteins, became apparent within 4-6 hours, and all the cells died by ...

Masahiro Mizuno, S. J. Singer, A Soluble Secretory Protein is First Concentrated in the Endoplasmic Reticulum Before Transfer to the Golgi Apparatus, Proceedings of the National Academy of Sciences of ...

PtdIns (3)P-bound UVRAG coordinates Golgi–ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex ...

Conclusions: Our findings provide proof-of-concept that targeting ER-Golgi homeostasis is therapeutically beneficial in lung cancer cell lines. No significant financial relationships to disclose. This ...

Immunogold labeling of Exoc5-myc (a component of the exocyst) in MDCK cells shows black dots along the primary cilium (arrowheads) and associated vesicles (arrows). The image was taken at 53,400X ...

The Golgi apparatus modifies, sorts and packages proteins to be sent to their final destinations, whether that's within or outside of the cell. It's a core function, but little studied in the ...

John S. Greenwood, Maarten J. Chrispeels, Immunocytochemical localization of phaseolin and phytohemagglutinin in the endoplasmic reticulum and Golgi complex of developing bean cotyledons, Planta, Vol.