DFMO May Affect Barrett's Esophagus Date: November 16, 2008 Source: American Association for Cancer Research Summary: Pilot study results suggest that difluoromethylornithine can modulate ...

The reduction in risk of adenoma recurrence from DFMO+sulindac vs placebo in the dietary polyamine intake quartiles 1–3 (i.e., 3/4ths of the study population) supports ODC inhibition as a ...

Marley's ODC1 gene mutation caused her body to accumulate lots of ODC protein which was building up in her system. Bachmann knew from his previous work that DFMO deactivates ODC proteins.

Eflornithine (DFMO) to reduce risk of relapse after completion of immunotherapy was investigated previously in a single-arm, phase II study (NMTRC003B; ClinicalTrials.gov identifier: NCT02395666) that ...

A paper published September 27 in Scientific Reports shows the positive results of a phase II clinical trial using the oral medication DFMO to prevent relapse in children with High Risk Neuroblastoma.

April 15, 2008 (San Diego, California) — Combining low-dose difluoromethylornithine (DFMO) and the nonsteroidal anti-inflammatory drug (NSAID) sulindac lowers the risk for recurrent colorectal ...

Notable adverse events associated with DFMO were changes in liver function tests, myelosuppression, and hearing loss. ODAC will convene at 9:30 a.m. ET Wednesday, and the meeting can be viewed ...

For adenoma burden, the mean percentage change at 6 months was – 40% for the patients prescribed CXB combined with DFMO, compared with – 27% for the patients prescribed CXB alone (P = .13).

A Phase 1 clinical study showed that high dose DFMO treatment in combination with chemotherapy may provide therapeutic benefits to heavily pretreated patients with neuroblastoma.MINNEAPOLIS, Jan ...

Healio News Hematology/Oncology Melanoma/Skin Cancer Issue: November 25, 2011 November 25, 2011 1 min read Save ...

MINNEAPOLIS, April 10, 2023 (GLOBE NEWSWIRE) -- Panbela Therapeutics, Inc. (Nasdaq: PBLA), a clinical stage biopharmaceutical company developing disruptive therapeutics for the treatment of ...