Dana-Farber researchers have provided the mechanistic and preclinical evidence needed to support a clinical trial of a new ...

No Pocket = No Correct Cell Division The research team, led by Thomas Mayer, has demonstrated this mechanism in two cyclins from the B group. Cyclin B1 plays a role in mitosis, a type of cell ...

The cells depleted of cyclins were exposed to Delta, Alpha, and wildtype SARS-CoV-2 variants multiple times to investigate the functional role of D-cyclins in SARS-CoV-2 pathogenesis.

Olga A. Koroleva, Matthew Tomlinson, Piyarat Parinyapong, Lali Sakvarelidze, David Leader, Peter Shaw, John H. Doonan, CycD1, a Putative G1 Cyclin from Antirrhinum majus, Accelerates the Cell Cycle in ...

D-type cyclins and their cyclin-dependent kinases are not essential for cell cycle progression, according to two independent reports in Cell this week. The studies reveal the existence of a previously ...

Initial analysis identified expected findings (eg, outlier overexpression of CDK4 in 39%-66% of WD-LPSs/DD-LPSs), clinical correlates of fundamental scientific work (eg, CCND1 in 29% of Ewing sarcomas ...

My laboratory has also held an interest in understanding how extrinsic signals influence B lymphocyte growth and survival. We have focused on investigating the regulation and function of D-type ...

Serizay and his colleagues recently posted a preprint that also outlined this variant cell cycle in multiciliated cells. 3 While they found a similar cyclic gene expression pattern that drove the ...

Nature Cell Biology - Cell cycles explainedThis well-structured and accessible textbook begins with an introduction to the general concept of discrete cell-cycle phases and basic mechanisms of ...