Previously, CXCL16 had been connected with the pathogenesis of lung injury. This is because of its function as a chemoattractant for CXCR6+ T, natural killer (NK), B, and dendritic cells (DC).

The CXCR6/CXCL16 signalling axis represents a pivotal mediator in the intricate interplay between immune responses, tumour progression and vascular pathology. CXCL16 exists both as a membrane ...

Might the CXCL16-CXCR6 pathway also be active within brain tissue? Indeed, Piehl found that in people with AD, plaque-associated microglia expressed abundant CXCL16, and CXCR6-expressing T cells ...

Elevated CXCL16 has been proposed as a useful predictive marker for liver metastasis and overall survival in CRC. In vitro, CXCL16/CXCR6 axis might play an importance role in mediating cell survival, ...

Eva Billerbeck, Yu-Hoi Kang, Lucy Walker, Helen Lockstone, Stefanie Grafmueller, Vicki Fleming, Jonathan Flint, Chris B. Willberg, Bertram Bengsch, Bianca Seigel, Narayan Ramamurthy, Nicole Zitzmann, ...

A molecular handshake slows Alzheimer's disease The two surface proteins, CXCR6 and CXCL16, essentially performed a handshake between the two cells, communicating in both directions. Just like the ...

Previous studies found that specific receptor of CXCL16, CXCR6, was significantly overexpressed in breast cancer tissues and metastatic axillary lymph nodes. We suppose whether CXCR6/CXCL16 axis is ...

Kazushige Obata-Ninomiya, Kenji Ishiwata, Hisanobu Nakano, Yusuke Endo, Tomomi Ichikawa, Atsushi Onodera, Kiyoshi Hirahara, Yoshitaka Okamoto, Hirotaka Kanuka, Toshinori Nakayama, CXCR6⁺ST2⁺ memory T ...