On the cell’s surface, both halves of the anti-CD3 paratope associate to form a complex able to bind and activate T cells. Importantly, formation of the active anti-CD3 complex cannot occur when ...

When naive T cells encounter antigen-presenting cells (APCs), membrane and cytoplasmic molecules rearrange at the T cell–APC contact area to form the immune synapse. Finetti et al. now reveal an ...

CD20 × CD3 bispecific antibodies bind to both CD20 on malignant B cells and CD3 on T cells, bringing them into close proximity, which triggers T cell-mediated killing of the targeted B cells.