Carpenito et al. have generated a CAR that recognizes mesothelin via the SS1 scFv and utilizes the intracellular signaling domains of CD3ζ, CD28 and CD137. [147] ...

Dysregulated AKT phosphorylation following CD28 co-stimulation Mechanistically, the study identified that PP2A maintains CD8+ T cell effector functions through modulation of the PI3K-AKT signaling ...

Rondo Therapeutics Publishes Preclinical Data on RNDO-564, a Novel CD28 x Nectin-4 Co-Stimulatory Bispecific Antibody for the Treatment of Bladder Cancer Provided by Business Wire Apr 8, 2025, 4: ...

This collaboration will combine Rondo Therapeutics’ proprietary CD28 co-stimulatory platform with Lilly’s drug development and commercialization expertise to develop co-stimulatory bispecific ...