BAP1 cancer syndrome: malignant mesothelioma, uveal and cutaneous melanoma, and MBAITs. Journal of Translational Medicine , 2012; 10 (1): 179 DOI: 10.1186/1479-5876-10-179 Cite This Page : ...

Missing BAP1 gene associated with immunosuppressive molecules in uveal melanoma. ScienceDaily . Retrieved April 30, 2025 from www.sciencedaily.com / releases / 2020 / 04 / 200409093959.htm ...

Germline mutations in the BAP1 gene may be associated with melanocytic BAP1–mutated atypical intradermal tumors, according to recent findings.The researchers suggest there is evidence that these ...

The atypical moles tend to be an irregular shape or colour. They also have a tendency to become cancerous. People with moles like this have a higher than average risk of skin melanoma and eye melanoma ...

About The Study: This study found that BRCA1-associated protein (BAP1) tumor predisposition syndrome was associated with a high rate of nail abnormalities consistent with onychopapillomas (a ...

Mesotheliomas are highly aggressive cancers with short overall survival, which can be extended only by a few months with currently approved therapies. Around 60%-70% of malignant mesotheliomas present ...

In this binding mode, the active site of BAP1 is located far away from the conventional H2AK119 position on the nucleosome, and the H2A C-terminal tail undergoes a large conformational change ...

“BAP1 is a tumor suppressor gene (that) is … known to be associated with aggressive RCC tumors and regulates key cellular pathways, including the (DNA repair) pathway,” Ged said in a presentation of ...

Of the 18,108 BAP1 variations, 11,912 were constant, 5,665 depleted, and 531 enriched. Unchanged variations received no functional evaluations, but enriched variants obtained better scores.

New evidence suggests that a novel, benign nail finding may facilitate the detection of BRCA1-associated protein tumor predisposition syndrome which leaves patients at risk for certain cancers ...

BRCA1-associated protein 1 (BAP1) was found to inhibit the browning of white adipose tissue in response to cold exposure in mice, offering a potential new drug target for a therapeutic strategy to ...