Of the 18,108 BAP1 variations, 11,912 were constant, 5,665 depleted, and 531 enriched. Unchanged variations received no functional evaluations, but enriched variants obtained better scores.

Saturation genome editing of BAP1 functionally classifies somatic and germline variants. Nature Genetics, 2024; DOI: 10.1038/s41588-024-01799-3 ...

BRCA1-associated protein 1 (BAP1) is a critical cell cycle and DNA damage response (DDR) regulator with mutations (mBAP1) causing a functional protein loss. PARP inhibitors (PARPis) demonstrate ...

BRCA1-associated protein 1 (BAP1) was found to inhibit the browning of white adipose tissue in response to cold exposure in mice, offering a potential new drug target for a therapeutic strategy to ...

BAP1 is mutated, leading to a loss of functional protein, in up to 30% of cholangiocarcinomas as well as several other solid tumors. Methods: This phase 2, open-label, single arm multicenter study ...

Patients with renal cell carcinoma (RCC) whose tumors had gene mutations such as BAP1 derived responses with favorable side effect profiles when treated with Lynparza (olaparib), as demonstrated by ...

Thompson IM et al. The influence of finasteride on the development of prostate cancer. N Engl J Med 2003 Jul 17; 349:215-24. Scardino PT. The prevention of prostate cancer -- The dilemma continues.