Compared with most intracellular vesicles, the autophagosome is formed by an unusual event of vesicle budding involving an elusive sequence of membrane expansions that ends with a double membrane ...

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Selective cargoes can also initiate autophagosome formation by recruiting specific ATG proteins and are recognized by the autophagosomal membrane at the nucleation–elongation step (Figure 1).

The researchers found that transmembrane cargo receptors can initiate autophagosome biogenesis through two distinct pathways: one by recruiting the upstream FIP200/ULK1 complex and another by ...

The involvement of mitochondrial dysfunction in neurodegeneration is exemplified by Parkinson's disease. 64 The mobilization of dysfunctional mitochondria to the autophagosome for turnover (i.e ...