Such ANGPTL4 activity can lead to blood vessel overgrowth and lack of vision improvement. “We have previously reported that ANGPTL4 was increased in patients who did not respond well to anti ...

Atherosclerotic plaques from mice without ANGPTL4 in fat tissues (bottom) are smaller, with less lipid accumulation (red), compared to those from mice with ANGPTL4 (top). Binod Aryal and Abhishek ...

Such ANGPTL4 activity could promote more damaging blood vessel overgrowth, researchers said. The team then investigated ways to limit ANGPTL4 levels, using an experimental drug on mice with wet AMD.

Meanwhile, Angptl4 was also found to participate in a feedback loop underway locally in skeletal muscle, heart muscle and in the adipose tissue that stores fat.

ANGPTL4 & Lipoprotein Lipase Inhibition Once secreted in the blood, ANGPTL4 inhibits the activity of blood lipoprotein lipase, an enzyme responsible for the conversion of triglycerides to ...

Angiopoietin-like 4 (ANGPTL4) is a glycosylated and secreted protein that functions as a regulator of cell metabolism and angiogenesis, and which has been shown to play a critical role in ...

The blow-up shows a single vesicle containing ANGPTL4 at several consecutive time points. FMNL2 (green) induces the polymerization of actin filaments (white) at the vesicle, propelling it forward.

Atherosclerotic cardiovascular disease (ASCVD) remains a leading cause of mortality worldwide despite advances in managing classic risk factors and therapies lowering LDL-cholesterol. Inhibiting ...

To conclude, it is clear that ANGPTL4 is a multifunctional signal protein, involved in many physiological processes and crosstalk associated with a variety of health effects. Its function depends ...

This second protein, ANGPTL4, also can stimulate overproduction of abnormal blood vessels in the retina, researchers reported Nov. 4 in the Proceedings of the National Academy of Sciences.